Oral Lesions Associated with COVID-19 and the Participation of the Buccal Cavity as a Key Player for Establishment of Immunity against SARS-CoV-2Article Published on 2022-09-092022-11-15 Journal: International Journal of Environmental Research an [Category] SARS, 치료제, [키워드] acute respiratory syndrome Antiviral article Autoimmunity Buccal carried Case report Cavity cavity buccal coronavirus coronavirus disease COVID-19 database described disorders Effect Immunity immunodeficiency Inflammatory response Interaction knowledge lesion manifestation mucosal immune oral oral lesion. pandemic Participation Patient patients with COVID-19 plaques raised SARS-CoV-2 selected the patient tongue vesicles virus with COVID-19 [DOI] 10.3390/ijerph191811383 PMC 바로가기
Identification, optimization, and biological evaluation of 3-O-β-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein스파이크 단백질의 융합 전 상태를 표적으로 하는 신규 SARS-CoV-2 진입 억제제로서의 3-O-β-chacotriosyl ursolic acid 유도체의 식별, 최적화 및 생물학적 평가Article Published on 2022-08-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral activity Antiviral agents Cavity COVID-19 pandemic Delta derivative effective generate identification Infection inhibitor inhibitors membrane fusion Mutation offer omicron Pentacyclic triterpenoid saponins prefusion pseudotyped SARS-CoV-2 public health S protein S1 and S2 saponins SARS SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein SARS-CoV-2 variant SARS. Spike protein subunit the S protein the SARS-CoV-2 Vaccine variant variants Vero-E6 cell Vero-E6 cells virus-cell membrane fusion [DOI] 10.1016/j.ejmech.2022.114426 PMC 바로가기 [Article Type] Article
Label-Free Detection of the Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein at Physiologically Relevant Concentrations Using Surface-Enhanced Raman Spectroscopy표면 강화 라만 분광법을 사용하여 생리학적으로 관련된 농도에서 SARS-CoV-2 스파이크 당단백질의 수용체 결합 도메인의 무표지 검출Article Published on 2022-05-052022-09-11 Journal: Biosensors [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] AFM Analysis analyte Antigen approach Cavity characteristic Concentration conformational detection develop Factor film glycoprotein group Interaction magnitude media optical pathogen Protein Radiation raising Raman spectroscopy RBD Receptor-binding domain reduced required S glycoprotein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 viral scattering sensitivity SERS silver Spectroscopy spike sulfhydryl surface-enhanced Raman spectroscopy. the RBD the receptor-binding domain the SARS-CoV-2 variant variants Viral antigen viral antigens Viral protein virus Volume [DOI] 10.3390/bios12050300 PMC 바로가기 [Article Type] Article
A Dispersion Corrected DFT Investigation of the Inclusion Complexation of Dexamethasone with β-Cyclodextrin and Molecular Docking Study of Its Potential Activity against COVID-19β-Cyclodextrin과 Dexamethasone의 포함 복합체에 대한 분산 수정 DFT 조사 및 COVID-19에 대한 잠재적 활성에 대한 분자 도킹 연구Article Published on 2021-12-152022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] β-cyclodextrin 6LU7 active site active sites activity approach AutoDock AutoDock vina binding Bioavailability calculated Cavity characterization complex complexation computation COVID-19 Density functional theory Dexamethasone DFT-D4 dispersion encapsulation ENhance free energy functional hydrogen Hydrogen bond hydrogen bonds inhibitor inhibitory activity Interaction investigated investigation molecular docking Molecular docking study non-covalent interactions PDB PDB ID PDB ID: 6LU7 Potential predicted protease Protease inhibitor Protein reducing SARS CoV-2 Side effects significantly target protein therapeutic activity van der Waal van der Waals interactions was performed [DOI] 10.3390/molecules26247622 PMC 바로가기 [Article Type] Article
Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity ResonatorMicrowave Immunosensor Cavity Resonator를 사용한 코로나바이러스(COVID-19)의 신속한 감지Article Published on 2021-10-232022-09-10 Journal: Sensors (Basel, Switzerland) [Category] MERS, SARS, 치료기술, [키워드] Accuracy amplitude Analysis automatically can be used Cavity change composed coronavirus COVID-19 detection Device Diagnosis diagnostic Diagnostic method diagnostics electrical property electromagnetic sensing ELISA Frequency Health crisis hospitals infected cases Infection international public health Laboratory limit micro-immunosensor microwave microwave cavity resonator (MCR) offer pandemic coronavirus parameter performed pocket vector network analyzer (VNA) Predictive proof quarantine Rapid rapid response real-time polymerase chain reaction (RT-PCR) receiver receiver operating characteristic Reflection reflection coefficient Resonator ROC rural areas SARS-CoV-2 virus sensor serum sample serum samples Spread the SARS-CoV-2 virus virus weight [DOI] 10.3390/s21217021 PMC 바로가기 [Article Type] Article
Can the Nasal Cavity Help Tackle COVID-19?Review Published on 2021-10-032022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] administration alternative route applied approach approved Can Cavity COVID-19 COVID-19 pandemic information intranasal delivery medication nasal Nasal cavity nasal vaccine SARS-CoV-2 therapeutic strategy Vaccine [DOI] 10.3390/pharmaceutics13101612 PMC 바로가기 [Article Type] Review
Interplay Among the Oral Microbiome, Oral Cavity Conditions, the Host Immune Response, Diabetes Mellitus, and Its Associated-Risk Factors—An OverviewOral Health Published on 2021-09-092022-10-31 Journal: Frontiers in Oral Health [Category] COVID-19, [키워드] addition advanced age affected aggravate alteration association bidirectional relationship blood pressure bloodstream Care Cavity complications condition conditions contribute decrease Diabetes Mellitus disease Effect elevated exacerbate exacerbating exaggerated inflammatory response Frequency fungal infections glycemic glycemic control greater HDL Health Host immune response hyperglycemia hyperlipidemia hypertension immune response immune system increase increase in individual individuals induce Inflammatory response insulin insulin resistance lesion likelihood management mechanism microbial microbial community Microbiome Nitrate nitrite obese obesity oral oral cavity Oral microbiome oral mucosa oxidative stress pathogen Patient patients periodontal disease Prevalence pro-inflammatory mediator progression reduce reduction response risk factor Risk factors salivary SARS-COV-2 infection secretion selective syndrome Triglyceride [DOI] 10.3389/froh.2021.697428 PMC 바로가기 [Article Type] Oral Health
Development of cavitary lung disease as a long-term complication of coronavirus disease 2019 in a young previously healthy patient: a case reportCase Report Published on 2021-07-132022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, SARS, [키워드] Acute inflammation Case report Cavitary lung lesion Cavity Chest computed tomography chest pain chills clinician Conservative management coronavirus disease COVID-19 development Evidence Fever healthy healthy individuals hospital IMPROVE Infection lung Lung disease male manifestation microorganisms Necrosis pleuritic pulmonary disease recognize reported SARS-CoV-2 Shortness of breath surgical surgical pathology therapy tissue variety while [DOI] 10.1186/s13256-021-02961-9 PMC 바로가기 [Article Type] Case Report
Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design심층 돌연변이 스캐닝 및 구조 기반 설계를 사용한 SARS-CoV-2 스파이크 수용체 결합 도메인의 안정화Immunology Published on 2021-06-292022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 비임상, 진단, [키워드] aggregation antigen stabilization antigenicity binding pocket breath candidate Cavity Characteristics clinical trial computational protein design coronavirus coronavirus vaccine deep deep mutational scanning demonstrated displaying effective evaluated expressed highlight immunogen IMPROVE lead linoleic acid Mutation nanoparticle phase presenting preserved Protein RBD Receptor-binding domain reported robust SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines scalability scanning Screening selected shown spike Spike protein stability the RBD the receptor-binding domain the SARS-CoV-2 thermal stability utility Vaccine vaccine candidate vaccine candidates Vaccine design variant wild-type [DOI] 10.3389/fimmu.2021.710263 PMC 바로가기 [Article Type] Immunology
Impact of COVID-19 Pandemic on Pre-Treatment Delays, Detection, and Clinical Characteristics of Tuberculosis Patients in Ningxia Hui Autonomous Region, China코로나19 팬데믹이 중국 닝샤후이족 자치구 결핵 환자의 치료 전 지연, 발견 및 임상 특성에 미치는 영향Public Health Published on 2021-05-212022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 치료기술, [키워드] average baseline case finding Cavity China clinical Clinical characteristics Contact tracing COVID-19 COVID-19 epidemic detection diagnosed Diagnosis dropped Impact impacted information management Intensive Local lockdown manifestation National Ningxia pandemic pandemic of COVID-19 Patient pre-treatment delay Public health intervention Public health interventions Region severity significantly significantly higher sputum Symptom System TB control TB patient TB patients Tuberculosis X-ray [DOI] 10.3389/fpubh.2021.644536 PMC 바로가기 [Article Type] Public Health